Actinine-d9 (chloride)

Actinine-d9 chloride is the deuterium labeled Actinine chloride. Actinine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat[1][2].

Product Specifications

CAS Number

[85806-17-3]

Product Name Alternative

γ-Butyrobetaine-d9 (hydrochloride) ; Deoxycarnitine-d9 (hydrochloride)

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

98.01

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[2H]C([N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCCC(O)=O)([2H])[2H].[Cl-]

Molecular Formula

C7H7D9ClNO2

Molecular Weight

190.72

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Koeth RA, et al. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 4;20 (5) :799-812.|[3]Susumu Ogawa, et al. The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function. Ogawa et al., J Nephrol Ren Dis 2017, 1:2