YM-58790
YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with Ki values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats[1].
Product Specifications
CAS Number
[214558-72-2]
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/YM-58790.html
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1CCN(CC2=CC=C(NC)C=C2)CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl
Molecular Formula
C27H32ClN3O2
Molecular Weight
466.01
References & Citations
[1]Naito R, et al. Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives. Chem Pharm Bull (Tokyo) . 1998 Aug;46 (8) :1274-85.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MAChR1; mAChR2; mAChR3
Available Sizes
Curated Selection
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