2-PMPA (sodium)

2-PMPA sodium is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.

Product Specifications

CAS Number

[373645-42-2]

Product Name Alternative

2- (Phosphonomethyl) pentanedioic acid (sodium)

UNSPSC

12352211

Target

Carboxypeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-pmpa-sodium.html

Purity

99.9

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C(CP(O[Na])(O[Na])=O)CCC(O[Na])=O

Molecular Formula

C6H7Na4O7P

Molecular Weight

314.05

References & Citations

[1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) . J Pharm Biomed Anal. 2014 Jan;88:162-9.|[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.|[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26 (1) :1-15.|[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51 (7-8) :1163-71.