BCAT-IN-2

BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6) . BCAT-IN-2 can be used for the research of obesity and dislipidema[1].

Product Specifications

CAS Number

[1800024-45-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aminotransferases (Transaminases)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bcat-in-2.html

Concentration

10mM

Purity

99.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=C2NC(CCC)=CC(N2N=C1NCC3=C(F)C=C(Cl)C=C3F)=O

Molecular Formula

C17H14ClF2N5O

Molecular Weight

377.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Bertrand SM, et, al. The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. J Med Chem. 2015 Sep 24;58 (18) :7140-63.