BpV (phen)

BpV (phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV (phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV (phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ) . bpV (phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].

Product Specifications

CAS Number

[42494-73-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Parasite; Phosphatase; PTEN

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bpv-phen.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.[K+]

Molecular Formula

C12H8KN2O5V

Molecular Weight

350.24

Precautions

H315, H319, H335

References & Citations

[1]Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55 (9) :741-748.|[2]Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262 (2) :265-75.|[3]Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566 (1-3) :35-8.|[4] Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV (phen) ] are insulin receptor kinase (IRK) -dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase (s) by bpV (phen) . Mol Endocrinol. 1997 Dec;11 (13) :1899-910.|[5]Chen Q, et al. Potassium Bisperoxo (1,10-phenanthroline) oxovanadate (bpV (phen) ) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290 (43) :26051-8.