UNC8732 (TFA)

UNC8732 (TFA) is a NSD2 inhibitor and degrader[1].

Product Specifications

CAS Number

[2929304-06-1]

UNSPSC

12352005

Target

Histone Methyltransferase; Molecular Glues

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc8732-tfa.html

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(F)(F)F)O.O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C6C(CCN(C6)C(CCCCCN)=O)=C5

Molecular Formula

C37H40F3N5O7

Molecular Weight

723.74

References & Citations

[1]David Y Nie, et al. Recruitment of FBXO22 for targeted degradation of NSD2. Nat Chem Biol. 2024 Dec;20 (12) :1597-1607.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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