Pellitorine

Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4) . Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[18836-52-7]

UNSPSC

12352211

Hazard Statement

H301, H315, H317, H319

Target

Amyloid-β; Bacterial; Dihydroorotate Dehydrogenase; ERK; Ferroptosis; Glutathione Peroxidase; Heme Oxygenase (HO) ; Insecticide; Keap1-Nrf2; NF-κB; PAI-1; Proton Pump; Thrombin; Toll-like Receptor (TLR) ; TRP Channel

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pellitorine.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)CNC(/C=C/C=C/CCCCC)=O

Molecular Formula

C14H25NO

Molecular Weight

223.35

Precautions

H301, H315, H317, H319

References & Citations

[1]Ee GC, et al. Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum. Molecules. 2010;15 (4) :2398-2404.|[2]Oláh Z, et al. Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1. Phytomedicine. 2017 Oct 15;34:44-49.|[3]Perumalsamy H, et al. Novel histopathological and molecular effects of natural compound pellitorine on larval midgut epithelium and anal gills of Aedes aegypti. PLoS One. 2013 Nov 18;8 (11) :e80226. |[4]Zhang JB, et al. Pellitorine protects chronic restraint stress-induced cognitive deficits via inhibiting neural inflammation and ferroptosis. Int Immunopharmacol. 2025 Sep 23;162:115166. |[5]Ku SK, et al. Antithrombotic activities of pellitorine in vitro and in vivo. Fitoterapia. 2013 Dec;91:1-8. doi: 10.1016/j.fitote.2013.08.004. Epub 2013 Aug 22. |[6]Lee W, et al. Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo. Fitoterapia. 2014 Jan;92:177-87. |[7]Reddy SV, et al. Antibacterial constituents from the berries of Piper nigrum. Phytomedicine. 2004 Nov;11 (7-8) :697-700.