Valproic acid
Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].
Product Specifications
CAS Number
[99-66-1]
Product Name Alternative
VPA; 2-Propylpentanoic acid; Dipropylacetic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H360
Target
Apoptosis; Autophagy; Endogenous Metabolite; HDAC; HIV; Mitophagy; Notch; Organoid
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/valproic-acid.html
Purity
99.72
Solubility
0.1 M NaOH : 50 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCC(CCC)C(O)=O
Molecular Formula
C8H16O2
Molecular Weight
144.21
Precautions
H302, H315, H319, H360
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HDAC; HDAC1; HDAC2
Citation 01
Available Sizes
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