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Thyrotropin

Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13].

Product Specifications

Product Name Alternative

TSH; Pretiron

UNSPSC

12352211

Target

Apoptosis; PKC; TSH Receptor

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; GPCR/G Protein; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/thyrotropin.html

Purity

95

Solubility

10 mM in DMSO

Smiles

[Thyrotropin]

References & Citations

[1]Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60 (11) :374-7. |[2]Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13 (3) :596-611.|[3]Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106 (12) :e4809-e4821.|[4]Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34 (2) :261-273.|[5]Ono H, et al. Involvement of thyrotropin in photoperiodic signal transduction in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105 (47) :18238-42.|[6]Marians RC, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99 (24) :15776-81.|[7]Colzani RM, et al. The effect of recombinant human thyrotropin (rhTSH) on thyroid function in mice and rats. Thyroid. 1998 Sep;8 (9) :797-801.|[8]van der Weerd K, van Hagen PM, Schrijver B, Heuvelmans SJ, Hofland LJ, Swagemakers SM, Bogers AJ, Dik WA, et al. Thyrotropin acts as a T-cell developmental factor in mice and humans. Thyroid. 2014 Jun;24 (6) :1051-61.|[9]Denef JF, et al. The influence of thyrotropin and growth hormone on the thyroid gland in the hereditary dwarf mouse: a morphometric study. Endocrinology. 1980 Oct;107 (4) :1249-57.|[10]Winand R J, et al. Thyrotropin effects on thyroid cells in culture. Effects of trypsin on the thyrotropin receptor and on thyrotropin-mediated cyclic 3': 5'-AMP changes. Journal of Biological Chemistry, 1975, 250 (16) : 6534-6540.|[11]Medina DL, et al. Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol. 2000 Aug;143 (2) :161-78.|[12]Dumont JE, et al. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 1992 Jul;72 (3) :667-97.|[13]Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140 (12) :5962-70.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Launched

CAS Number

[9002-71-5]

Available Sizes

Curated Selection

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