CZL80
CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility[1].
Product Specifications
CAS Number
[313482-91-6]
UNSPSC
12352005
Target
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/czl80.html
Purity
98.31
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(O)C1=CC=CC(NC(C2=CC=CC(NC(C3=CC=CS3)=O)=C2)=O)=C1
Molecular Formula
C19H14N2O4S
Molecular Weight
366.39
References & Citations
[1]Yangshun Tang, et al. Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility. Br J Pharmacol. 2020 Aug;177 (15) :3519-3534.|[2]Ling Pan, et al. Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window. Acta Pharmacol Sin. 2022 Nov;43 (11) :2817-2827.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1
Available Sizes
Curated Selection
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