CSF1R-IN-12
CSF1R-IN-12 (compound 1) is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-12 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
[2361556-35-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csf1r-in-12.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(NCC2=CN=C(C=C2)C(F)(F)F)=NC=C1C3=CC=CC4=C3CNC4=O
Molecular Formula
C21H17F3N4O
Molecular Weight
398.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Wenyun Qian, et al. Isoindolinone and derivative thereof as csf-1r inhibitor. Patent WO2019134661A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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