ST247

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].

Product Specifications

CAS Number

[1356497-91-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/st247.html

Purity

99.88

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C1=C(S(=O)(NC2=CC=C(NCCCCCC)C=C2OC)=O)C=CS1)OC

Molecular Formula

C19H26N2O5S2

Molecular Weight

426.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80 (5) :828-38.