Thioflavin T

Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free) ; ~450 nm (bound) ; Emission max.: ~445 nm (free) ; ~485 nm (bound) [1][2][3].

Product Specifications

CAS Number

[2390-54-7]

Product Name Alternative

Basic Yellow 1

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Dye Reagents

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Thioflavin_T.html

Purity

98.23

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC=C2[N+](C)=C(C3=CC=C(N(C)C)C=C3)SC2=C1.[Cl-]

Molecular Formula

C17H19ClN2S

Molecular Weight

318.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151 (3) :229-38.|[2]Nakano H, et al. Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation. Neurobiol Dis. 2025 Feb;205:106775.|[3]Muramatsu D, et al. ALZ-801 prevents amyloid β-protein assembly and reduces cytotoxicity: A preclinical experimental study. FASEB J. 2025 Feb 15;39 (3) :e70382.