(S) -FTY720-phosphonate

FTY720 (S) -Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

Product Specifications

CAS Number

[1142015-10-8]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-fty720-phosphonate.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

Smiles

O=P(O)(O)CC[C@@](CO)(N)CCC1=CC=C(C=C1)CCCCCCCC

Molecular Formula

C20H36NO4P

Molecular Weight

385.48

References & Citations

[1]Wang L, et al. FTY720 (s) -phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42 (3) :e189-99.|[2]Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.