ML154

ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively[1][2].

Product Specifications

CAS Number

[1345964-89-7]

Product Name Alternative

NCGC84

UNSPSC

12352005

Target

Neuropeptide S Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml154.html

Purity

99.59

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

S=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=C(C)[N+](C/C=C/C4=CC=CC=C4)=C5N3C=CC=C5.[Br-]

Molecular Formula

C29H26BrN2PS

Molecular Weight

545.47

References & Citations

[1]İrem Akçalı, et al. The regulatory role of central neuropeptide-S in locomotion. Peptides. 2023 Dec:170:171110.|[2]Annika Thorsell, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013 Jun 12;33 (24) :10132-42.