Mcl-1 inhibitor 19
Product Specifications
UNSPSC Description
Mcl-1 inhibitor 19 (compound 26) binds to Mcl-1, with the Ki of 86 pM. Mcl-1 inhibitor 19 inhibits growth in H929 cells with the GI of 43 nM[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-19.html
Smiles
ClC1=CC=C(C2=C1C3=C(N=C(N=C3C)C)C)C(CCCOC4=CC(C)=C(C(C)=C4)Cl)=C5N2[C@@H](CN(C5=O)C6=CC(OCC7CCOCC7)=C(C8=C6N(C(C(O)=O)=C8)C)OC)C
Molecular Weight
868.84
References & Citations
[1]James C Tarr, et al. Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors. J Med Chem. 2024 Aug 22;67(16):14370-14393.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162780/Mcl-1-inhibitor-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162780/
Clinical Information
No Development Reported
Curated Selection
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