TEAD-IN-11
Product Specifications
UNSPSC Description
TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].
Target Antigen
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tead-in-11.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=C(C#CC2CN(C(C=C)=O)CC2)C=C1
Molecular Weight
293.28
References & Citations
[1]Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161569/TEAD-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161569/
Clinical Information
No Development Reported
CAS Number
3032196-88-3
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Aluminum housed mantle for 22000ml spherical flask, high temp, 3 circuits each 1000W, 115V
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