Cimetidine

Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].

Product Specifications

CAS Number

[51481-61-9]

Product Name Alternative

SKF-92334

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Cimetidine.html

Purity

98.0

Solubility

DMSO : 60 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

CC1=C(CSCC/N=C(NC)/NC#N)NC=N1

Molecular Formula

C10H16N6S

Molecular Weight

252.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70 (2) : p. 450-3.|[2]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94 (5) : p. 585-92.|[3]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54 (1) : p. 74-83.|[4]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376.|[5]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.|[6]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6802-7.