Galloflavin

Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B) . Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].

Product Specifications

CAS Number

[568-80-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/galloflavin.html

Concentration

10mM

Purity

99.36

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC(C=C1O)=C2OC1=O)C3=C2C(O)=C(O)C(O)=C3

Molecular Formula

C12H6O8

Molecular Weight

278.17

Precautions

H302

References & Citations

[1]Manerba M, Vettraino M, Fiume L, et al. Galloflavin (CAS 568-80-9) : a novel inhibitor of lactate dehydrogenase. ChemMedChem. 2012;7 (2) :311-317. |[2]Farabegoli F, et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci. 2012;47 (4) :729-738. |[3]Han X, et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 2015;8:2. Published 2015 Jan 29.