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(-)-PX20606 (trans isomer)

Product Specifications

UNSPSC Description

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

Target Antigen

Autophagy; FXR

Type

Reference compound

Related Pathways

Autophagy;Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/minus-px20606-trans-isomer.html

Solubility

Ethanol : ≥ 50 mg/mL

Smiles

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1

Molecular Weight

554.85

References & Citations

[1]Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100443B/minus-PX20606-trans-isomer-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100443B/minus-PX20606-trans-isomer-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1268244-88-7

Available Sizes

Curated Selection

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