Cefmetazole

Cefmetazole (CS 1170) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative and anaerobic bacteria. Cefmetazole binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections[1][2][3].

Product Specifications

CAS Number

[56796-20-4]

Product Name Alternative

CS 1170

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H334, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/cefmetazole.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CCSCC(N[C@]1([C@]2([H])N(C(C(O)=O)=C(CS2)CSC3=NN=NN3C)C1=O)OC)=O

Molecular Formula

C15H17N7O5S3

Molecular Weight

471.53

Precautions

H315, H317, H319, H334, H335

References & Citations

[1]Truesdell SE, et, al. Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1989 Apr;23 Suppl D:13-9.|[2]Schentag JJ. Cefmetazole sodium: pharmacology, pharmacokinetics, and clinical trials. Pharmacotherapy. 1991;11 (1) :2-19.|[3]Yaguchi Y, et, al. Influences of long-term antibiotic administration on Peyer's patch lymphocytes and mucosal immunoglobulin A levels in a mouse model. JPEN J Parenter Enteral Nutr. 2006 Sep-Oct;30 (5) :395-8; discussion 399.