ASP8302

ASP8302 is a positive and allosteric muscarinic M3 receptor modulator. ASP8302 improves voiding efficiency and reduced residual urine volume in two voiding dysfunction models. ASP8302 can be used for research of underactive bladder[1][2].

Product Specifications

CAS Number

[1839583-42-4]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/asp8302.html

Purity

98.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=C(N2C[C@@H](N(CC2)CCC(O)=O)C)N=C1)NC(S3)=NC(C4=CC(Cl)=CS4)=C3CN5[C@@H](CCC5)C

Molecular Formula

C26H32ClN7O3S2

Molecular Weight

590.16

References & Citations

[1]Okimoto R, et al. Potentiation of Muscarinic M3 Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302. J Pharmacol Exp Ther. 2021 Oct;379 (1) :64-73. |[2]Okimoto R, et al. Muscarinic M3 positive allosteric modulator ASP8302 enhances bladder contraction and improves voiding dysfunction in rats. Low Urin Tract Symptoms. 2022 Jul;14 (4) :289-300.