(R) -eIF4A3-IN-2
(R) -eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].
Product Specifications
CAS Number
[2095484-82-3]
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/r-eif4a3-in-2.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@@H](C2=CC=C(Cl)C=C2)N(C(C3=CC=C(Br)C=C3)=O)CC1)C4=C5C=CC(Br)=CN5N=C4
Molecular Formula
C25H19Br2ClN4O2
Molecular Weight
602.70
References & Citations
[1]Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12 (7) :1760-1768.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4
Available Sizes
Curated Selection
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