AK59

AK59 is a STING degrader that works by leveraging HERC4, a hect domain E3 ligase. AK59 can be used in the study of autoimmune diseases and cancer[1].

Product Specifications

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ak59.html

Purity

99.79

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=S(NC1=C2N=CC=CC2=C(C=C1)C3=CC=CN=C3)(C4=CC=C(C=C4)C(F)(F)F)=O

Molecular Formula

C21H14F3N3O2S

Molecular Weight

429.41

References & Citations

[1]Mutlu M, et al. Small molecule induced STING degradation facilitated by the HECT ligase HERC4. Nat Commun. 2024 May 29;15 (1) :4584.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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