CX546

CX546 is a first-generation and selective benzamide-type positive AMPAR modulator. CX546 is a prototypical ampakine agent and has antipsychotic effects[1][2].

Product Specifications

CAS Number

[215923-54-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; iGluR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CX546.html

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(N1CCCCC1)C2=CC=C(OCCO3)C3=C2

Molecular Formula

C14H17NO3

Molecular Weight

247.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20 (1) :8-21.|[2]Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32 (4) :745-56.