Nilutamide

Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties[1][4].

Product Specifications

CAS Number

[63612-50-0]

Product Name Alternative

Nilandron; RU 23908

UNSPSC

12352005

Hazard Statement

H301, H360

Target

Androgen Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/nilutamide.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C([N+]([O-])=O)C(C(F)(F)F)=C2)C(C(C)(C)N1)=O

Molecular Formula

C12H10F3N3O4

Molecular Weight

317.22

Precautions

H301, H360

References & Citations

[1]Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3 (1) :9-25.|[2]Babany G, et al. Inhibitory effects of nilutamide, a new androgen receptor antagonist, on mouse and human liver cytochrome P-450. Biochem Pharmacol. 1989 Mar 15;38 (6) :941-7.|[3]Simard J, et al. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology. 1997 Apr;49 (4) :580-6; discussion 586-9.|[4]Keiser J, Vargas M, Vennerstrom JL. Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother. 2010 Sep;65 (9) :1991-5.