VS-5584

VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1.

Product Specifications

CAS Number

[1246560-33-7]

Product Name Alternative

SB2343

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vs-5584.html

Purity

98.71

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=C3N=C(C)N(C(C)C)C3=NC(N4CCOCC4)=N2)C=N1

Molecular Formula

C17H22N8O

Molecular Weight

354.41

Precautions

H315, H319, H335

References & Citations

[1]Hart S, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther, 2013, 12 (2), 151-161.