Disoxaril
Product Specifications
UNSPSC Description
Disoxaril (WIN-51711) is a polioviruses inhibitor. Disoxaril inhibits the replication of polioviruses types 1 and 2 in cells. Disoxaril binds directly to the virion capsid proteins and inhibits viral uncoating by stabilizing the virus capsid. Disoxaril still allows the virus to enter the cell by receptor-mediated endocytosis. Disoxaril also inhibits enterovirus replication[1][2].
Target Antigen
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/disoxaril.html
Smiles
CC1=NOC(CCCCCCCOC2=CC=C(C3=NCCO3)C=C2)=C1
Molecular Weight
342.43
References & Citations
[1]Zeichhardt H, et al. Inhibition of poliovirus uncoating by disoxaril (WIN 51711). Virology. 1987 Sep;160(1):281-5.|[2]Nikolova I, et al. Disoxaril mutants of Coxsackievirus B1: phenotypic characteristics and analysis of the target VP1 gene. Z Naturforsch C J Biosci. 2011 Nov-Dec;66(11-12):627-36.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111233/Disoxaril-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111233/
Clinical Information
No Development Reported
CAS Number
87495-31-6
Curated Selection
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