6-Hydroxybenzbromarone

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting[1].

Product Specifications

CAS Number

[152831-00-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/6-hydroxybenzbromarone.html

Concentration

10mM

Purity

99.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC(O)=CC=C23

Molecular Formula

C17H12Br2O4

Molecular Weight

440.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Pandey RN, et al. Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents.PLoS One. 2013 Dec 18;8 (12) :e84582.