Lithocholic Acid (Biotechnology Grade)

<strong>Lithocholic Acid (Biotechnology Grade)</strong>_x000D_ <strong>Catalog number:</strong> B2010631_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 500 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 376.57 g/mol_x000D_ <strong>Supplied as:</strong> Solid_x000D_ <strong>Applications:</strong> multipurpose tool in the study of bile acids_x000D_ <strong>Storage:</strong> RT_x000D_ <strong>Keywords:</strong> 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H,_x000D_ Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A. Lithocholic_x000D_ Acid Derivatives as Potent Vitamin D Receptor Agonists. J Med Chem. 2021 Jan_x000D_ 14;64(1):516-526._x000D_ _x000D_ 2: Sivcev S, Slavikova B, Ivetic M, Knezu M, Kudova E, Zemkova H. Lithocholic_x000D_ acid inhibits P2X2 and potentiates P2X4 receptor channel gating. J Steroid_x000D_ Biochem Mol Biol. 2020 Sep;202:105725._x000D_ _x000D_ 3: Hofmann AF. Detoxification of lithocholic acid, a toxic bile acid: relevance_x000D_ to drug hepatotoxicity. Drug Metab Rev. 2004 Oct;36(3-4):703-22._x000D_ _x000D_ 4: Masuno H, Kazui Y, Tanatani A, Fujii S, Kawachi E, Ikura T, Ito N, Yamamoto_x000D_ K, Kagechika H. Development of novel lithocholic acid derivatives as vitamin D_x000D_ receptor agonists. Bioorg Med Chem. 2019 Aug 15;27(16):3674-3681._x000D_ _x000D_ 5: do Nascimento PG, Lemos TL, Almeida MC, de Souza JM, Bizerra AM, Santiago GM,_x000D_ da Costa JG, Coutinho HD. Lithocholic acid and derivatives: Antibacterial_x000D_ activity. Steroids. 2015 Dec;104:8-15._x000D_ _x000D_ 6: Arlia-Ciommo A, Piano A, Svistkova V, Mohtashami S, Titorenko VI. Mechanisms_x000D_ underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int J_x000D_ Mol Sci. 2014 Sep 18;15(9):16522-43._x000D_ _x000D_ 7: Wong SY, Teo JSM, Chai SF, Yeap SL, Lau AJ. Vitamin E analogues_x000D_ differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative_x000D_ metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic_acid_x000D_ cytotoxicity. Toxicology. 2019 Jul 1;423:62-74._x000D_ _x000D_ 8: Grobe S, Badenhorst CPS, Bayer T, Hamnevik E, Wu S, Grathwol CW, Link A,_x000D_ Koban S, Brundiek H, Großjohann B, Bornscheuer UT. Engineering Regioselectivity_x000D_ of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via_x000D_ 7β-Hydroxylation of Lithocholic_Acid. Angew Chem Int Ed Engl. 2021 Jan_x000D_ 11;60(2):753-757._x000D_ _x000D_ 9: Gaikwad S, González CM, Vilariño D, Lasanta G, Villaverde C, Mouriño A,_x000D_ Verlinden L, Verstuyf A, Peluso-Iltis C, Rochel N, Berkowska K, Marcinkowska E._x000D_ Lithocholic acid-based design of noncalcemic vitamin D receptor agonists. Bioorg_x000D_ Chem. 2021 Jun;111:104878._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33179169/">10: Yang B, Zha R, Zhao W, Gong D, Meng X, Zhang Z, Zhu L, Qi N, Wang B._x000D_ Comparative transcriptome analysis of the fungus Gibberella zeae transforming_x000D_ lithocholic acid into ursodeoxycholic acid. Biotechnol Lett. 2021_x000D_ Feb;43(2):415-422.</a>_x000D_ _x000D_ <strong>Products Related to Lithocholic Acid (Biotechnology Grade)</strong><a href="https://moleculardepot.com/product-category/Chemicals/">: Chemicals</a>