BCI
BCI ((E) -BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2].
Product Specifications
CAS Number
[1245792-51-1]
Product Name Alternative
(E) -BCI
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bci.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4
Molecular Formula
C22H23NO
Molecular Weight
317.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15 (10) :1436-45.|[2]Zhang F, et al. DUSP6 Inhibitor (E/Z) -BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42 (2) :672-681.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2024 Feb 5.|Cells. 2022 Feb 19;11 (4) :732.|Dis Model Mech. 2023 May 1;16 (5) :dmm049662.|FASEB J. 2025 Jul 15;39 (13) :e70780.|Int Immunopharmacol. 2024 Sep 30;143 (Pt 1) :113280.|J Nanobiotechnology. 2025 Jun 6;23 (1) :422.|Kaohsiung J Med Sci. 2023 Mar;39 (3) :254-265.|Neural Regen Res. 2023 Aug;18 (8) :1743-1749.|Sci Rep. 2025 May 24;15 (1) :18115.|Cancer Med. 2024 Oct;13 (19) :e70276.|Cancers (Basel) . 2023 Sep 6;15 (18) :4442.|Cell Rep. 2025 Feb 20;44 (3) :115340.|Development. 2023 Mar 1;150 (5) :dev201090.|Phytother Res. 2023 Jul;37 (7) :2979-2994.|Transplant Proc. 2025 Aug 11:S0041-1345 (25) 00350-1.|University of Washington. 2025.
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