Bindarit

Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1].

Product Specifications

CAS Number

[130641-38-2]

Product Name Alternative

AF2838

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CCR

Type

Natural Products

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/bindarit.html

Purity

99.53

Solubility

DMSO : ≥ 46 mg/mL

Smiles

CC(OCC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)(C)C(O)=O

Molecular Formula

C19H20N2O3

Molecular Weight

324.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84 (3) : p. 485-93.|[2] Zoja C, Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int. 1998 Mar;53 (3) :726-34.