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DCOIT

DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR) -mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca2+ signaling cascades[1].

Product Specifications

CAS Number

[64359-81-5]

Product Name Alternative

Kathon 930

UNSPSC

12352005

Hazard Statement

H302, H314, H317, H330, H410

Target

GnRH Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/dcoit.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 133.33 mg/mL (ultrasonic)

Smiles

O=C1N(CCCCCCCC)SC(Cl)=C1Cl

Molecular Formula

C11H17Cl2NOS

Molecular Weight

282.23

Precautions

H302, H314, H317, H330, H410

References & Citations

[1]Tang L, et al. Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling. Environ Sci Technol. 2024 Jan 3.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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