5-trans-PGE2
Product Specifications
UNSPSC Description
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer[1].
Target Antigen
Cytochrome P450; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/5-trans-pge2.html
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C/CCCC(O)=O
Molecular Weight
352.47
References & Citations
[1]Richards JA, et al. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J Clin Endocrinol Metab. 2003 Jun;88(6):2810-6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135023/5-trans-PGE2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135023/
Clinical Information
No Development Reported
CAS Number
36150-00-2
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