ML171
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
Product Specifications
CAS Number
[6631-94-3]
Product Name Alternative
2-Acetylphenothiazine; 2-APT
UNSPSC
12352005
Hazard Statement
H302, H412
Target
NADPH Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ML171.html
Purity
99.79
Solubility
DMSO : ≥ 64 mg/mL
Smiles
CC(C1=CC=C2SC3=CC=CC=C3NC2=C1)=O
Molecular Formula
C14H11NOS
Molecular Weight
241.31
Precautions
H302, H412
References & Citations
[1]Gianni D, et al. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol. 2010 Oct 15;5 (10) :981-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOX1
Available Sizes
Curated Selection
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