Myricitrin

Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects[1][2][3][4][5].

Product Specifications

CAS Number

[17912-87-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase; Parasite; PKC; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/myricitrin.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC(O)=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14

Molecular Formula

C21H20O12

Molecular Weight

464.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Hwang IW, et al. Isolation and Identification of Myricitrin, an Antioxidant Flavonoid, from Daebong PersimmonPeel. Prev Nutr Food Sci. 2018 Dec;23 (4) :341-346.|[2]Domitrović R, et al. Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact. 2015 Mar 25;230:21-9. |[3]Shimosaki S, et al. Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo. Nat Prod Res. 2011 Feb;25 (4) :374-80. |[4]Y. Liu, N. et al. Antimalarial Flavonol Glycosides from Euphorbia hirta. Pharmaceutical Biology, Volume 45, 2007-Issue 4.|[5]Pereira M, et al. Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35 (7) :1636-44.