K 01-162

K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2].

Product Specifications

CAS Number

[677746-25-7]

Product Name Alternative

K162

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/K-01-162.html

Purity

98.0

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

BrC1=CC(CC2=C3C=CC(N(C)C)=C2)=C3C=C1

Molecular Formula

C15H14BrN

Molecular Weight

288.18

References & Citations

[1]Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100 (4) :1076-82.|[2]Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31 (10) :1690-9.