Melamine

Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models[1][2][3][4][5][6].

Product Specifications

CAS Number

[108-78-1]

UNSPSC

12352005

Hazard Statement

H361

Target

Apoptosis; COX; NADPH Oxidase; NF-κB; ROS Kinase; TGF-β Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/melamine.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 1 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=NC(N)=N1

Molecular Formula

C3H6N6

Molecular Weight

126.12

Precautions

H361

References & Citations

[1]Chang L, et al. In vitro toxicity evaluation of melamine on mouse TM4 Sertoli cells. Environ Toxicol Pharmacol. 2017 Mar;50:111-118.|[2]An L, et al. Melamine induced cognitive impairment associated with oxidative damage in rat's hippocampus. Pharmacol Biochem Behav. 2012 Aug;102 (2) :196-202. |[3]Tian XY, et al. Melamine Impairs Renal and Vascular Function in Rats. Sci Rep. 2016 Jun 21;6:28041|[4]Xie G, et al. Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J Proteome Res. 2010 Jan;9 (1) :125-33. |[5] An L, et al. Cognitive deficits induced by melamine in rats. Toxicol Lett. 2011 Oct 30;206 (3) :276-80.|[6]Ogasawara H, et al. Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation. Carcinogenesis. 1995 Nov;16 (11) :2773-7. |[7]Kuo FC, et al. Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. Toxicol In Vitro. 2013 Sep;27 (6) :1603-11.|[8]Xue M, et al. Plasma pharmacokinetics of melamine and a blend of melamine and cyanuric acid in rainbow trout (Oncorhynchus mykiss) . Regul Toxicol Pharmacol. 2011 Oct;61 (1) :93-7.