(S)-VU0637120
Product Specifications
UNSPSC Description
(S)-VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 μM. (S)-VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S)-VU0637120 holds potential for research in the field of metabolic diseases[1].
Target Antigen
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-vu0637120.html
Smiles
O=C([C@H]1N(CCCC1)S(C)(=O)=O)NC2=NC3=CC(OCCO4)=C4C=C3S2
Molecular Weight
397.47
References & Citations
[1]Schüß C, et al. Highly Selective Y Receptor Antagonist Binds in an Allosteric Binding Pocket. J Med Chem. 2021 Mar 11;64(5):2801-2814.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-165125/S-VU0637120-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-165125/
Clinical Information
No Development Reported
CAS Number
1175940-86-9
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