Ispinesib

Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

Product Specifications

CAS Number

[336113-53-2]

Product Name Alternative

SB-715992; CK-0238273

UNSPSC

12352005

Hazard Statement

H300+H330, H341

Target

Apoptosis; Kinesin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Ispinesib.html

Purity

99.74

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14

Molecular Formula

C30H33ClN4O2

Molecular Weight

517.06

Precautions

H300+H330, H341

References & Citations

[1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.