Indoprofen

Indoprofen ((±) -Indoprofe) activates AKT-AMPK signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active[1][2].

Product Specifications

CAS Number

[31842-01-0]

Product Name Alternative

(±) -Indoprofe

UNSPSC

12352005

Hazard Statement

H301, H351

Target

Akt; AMPK; NF-κB; p38 MAPK

Type

Reference compound

Related Pathways

Epigenetics; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Indoprofen.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1

Molecular Formula

C17H15NO3

Molecular Weight

281.31

Precautions

H301, H351

References & Citations

[1]Kim H, Cho SC, Jeong HJ, et al. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway. J Cachexia Sarcopenia Muscle. 2020;11 (4) :1070-1088. |[2]Bi X, et al., Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicol Appl Pharmacol. 2021 Dec 15;433:115778.