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URB694

URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2].

Product Specifications

CAS Number

[904672-77-1]

UNSPSC

12352005

Target

FAAH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/urb694.html

Solubility

10 mM in DMSO

Smiles

O=C(OC=1C=CC(O)=C(C1)C=2C=CC=CC2)NC3CCCCC3

Molecular Formula

C19H21NO3

Molecular Weight

311.37

References & Citations

[1]Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218.|[2]Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55 (12) :1993-7.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W728451/URB694-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W728451/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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