Urolithin C
Product Specifications
UNSPSC Description
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].
Target Antigen
Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/urolithin-c.html
Smiles
O=C1C2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3O1
Molecular Weight
244.20
References & Citations
[1]Slimane Toubal, et al. Urolithin C Increases Glucose-Induced ERK Activation Which Contributes to Insulin Secretion. Fundam Clin Pharmacol. 2020 Feb 21.|[2] Peipei Yin, et al. Urolithin C, a gut metabolite of ellagic acid, induces apoptosis in PC12 cells through a mitochondria-mediated pathway. RSC Advances. Issue 28, 2017.|[3]Morgane Bayle, et al. Development and Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for the Determination of Urolithin C in Rat Plasma and Its Application to a Pharmacokinetic Study. J Pharm Biomed Anal. 2016 Nov 30;131:33-39.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135897/Urolithin-C-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135897/Urolithin-C-SDS-MedChemExpress.pdf
CAS Number
165393-06-6
Available Sizes
Curated Selection
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