Streptomycin

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB) . Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes [1][2][3].

Product Specifications

CAS Number

[57-92-1]

Product Name Alternative

Agrept; Agrimycin; Streptomycin A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/streptomycin.html

Purity

99.91

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC

Molecular Formula

C21H39N7O12

Molecular Weight

581.57

Precautions

H302, H315, H319, H335

References & Citations

[1]J DAVIES, et al. STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proc Natl Acad Sci U S A. 1964 May;51 (5) :883-90.|[2]Deisy M G C Rocha, et al. The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem. Genes (Basel) . 2021 Dec 17;12 (12) :2003.|[3]Mandeep Singh, et al. Streptomycin sulphate loaded solid lipid nanoparticles show enhanced uptake in macrophage, lower MIC in Mycobacterium and improved oral bioavailability. Eur J Pharm Biopharm. 2021 Mar;160:100-124.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Aminoglycoside

Citation 01

ACS Appl Mater Interfaces. 2024 Sep 4;16 (35) :46123-46132.|Adv Sci (Weinh) . 2024 Nov;11 (44) :e2401931.|Adv Sci (Weinh) . 2025 Oct 13:e09383.|Anal Bioanal Chem. 2025 Jan;417 (3) :615-625.|APL Bioeng. 2022 Nov 21;6 (4) :046106.|BMC Cancer. 2023 Mar 14;23 (1) :241.|Cancers (Basel) . 2022 Sep 28;14 (19) :4740.|Food Chem. 2023 Mar 1:403:134399.|Food Funct. 2025 Feb 3;16 (3) :1041-1059.|Free Radic Biol Med. 2023 Jul:203:86-101.|Genome Biol. 2023 Apr 30;24 (1) :98.|Gut Microbes. 2024 Jan-Dec;16 (1) :2390164.|In Vitro Cell Dev Biol Anim. 2024 Oct;60 (9) :1046-1057.|Int Dent J. 2025 Jun 9;75 (4) :100850.|Int J Biol Sci. 2024 Sep 3;20 (12) :4635-4653.|Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251348715.|J Control Release. 2024 Oct 26:S0168-3659 (24) 00725-9.|J Med Chem. 2024 Sep 12;67 (17) :15387-15410.|J Med Chem. 2025 Mar 27;68 (6) :6339-6360.|J Nanobiotechnology. 2024 Nov 30;22 (1) :744.|J Orthop Surg Res. 2022 Oct 28;17 (1) :468.|Mar Life Sci Technol. 2025 May 12;7 (2) :256-270.|Microbiol Spectr. 2025 Aug 29:e0059025.|mLife. 2025 Apr 15;4 (2) :155-168.|Redox Biol. 2024 Jul 23:75:103284.|Research (Wash D C) . 2024 Jul 16:7:0415.|Transl Oncol. 2025 May:55:102355.|Water. 2025 Jun 6.|ACS Chem Biol. 2022 Jan 21;17 (1) :39-53.|ACS Omega. 2020 Nov 15;5 (46) :29935-29942.|Autophagy. 2022 Apr;18 (4) :726-744.|Cell Host Microbe. 2025 Jun 11;33 (6) :915-931.e9.|Cell Rep Med. 2023 Dec 19;4 (12) :101340.|Curr Res Food Sci. 2025 May 16:10:101084.|Dis Model Mech. 2021 Dec 1;14 (12) :dmm049145.|Drug Dev Res. 2022 Apr;83 (2) :389-396.|Life Sci. 2020 Nov 15;261:118473.|Mol Med Rep. 2021 Dec;24 (6) :832.|Mol Med Rep. 2021 Dec;24 (6) :843.|NPJ Biofilms Microbiomes. 2024 Oct 28;10 (1) :111.|PLoS One. 2020 Sep 3;15 (9) :e0235824.|Signal Transduct Target Ther. 2025 Mar 5;10 (1) :79.