JI069
JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.
Product Specifications
CAS Number
[850019-35-1]
UNSPSC
12352100
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ji069.html
Purity
98.03
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(COC(CC2=C(Cl)C=CC=C2Cl)=O)=O)SC=C1)N
Molecular Formula
C15H12Cl2N2O4S
Molecular Weight
387.24
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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