9-Methoxycamptothecin

9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

Product Specifications

CAS Number

[39026-92-1]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Topoisomerase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9-methoxycamptothecin.html

Concentration

10mM

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@@]1(C2=C(COC1=O)C(N3C(C4=NC5=CC=CC(OC)=C5C=C4C3)=C2)=O)O

Molecular Formula

C21H18N2O5

Molecular Weight

378.38

Precautions

H301

References & Citations

[1]Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66 (9-10) :471-6.|[2]Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.