BVFP
BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].
Product Specifications
CAS Number
[357158-20-4]
UNSPSC
12352005
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bvfp.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N=C(C=C(C(F)(F)F)N1)/C=C/C2=CC(Br)=CC=C2
Molecular Formula
C13H8BrF3N2O
Molecular Weight
345.11
References & Citations
[1]Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23 (6) :1467-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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