DAT1

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization[1].

Product Specifications

CAS Number

[107401-70-7]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dat1.html

Smiles

O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3

Molecular Formula

C17H15N3O2S

Molecular Weight

325.38

References & Citations

[1]Suparna Sengupta, et al. 4-Amino-5-benzoyl-2- (4-methoxyphenylamino) thiazole (DAT1) : a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145 (8) :1076-83. |[2]Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13 (1) :179-89.