Alectinib-d6
Product Specifications
Product Name Alternative
CH5424802-d6; RO5424802-d6; AF802-d6
UNSPSC Description
Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
Target Antigen
Anaplastic lymphoma kinase (ALK); Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC3=CC(C#N)=CC=C32)C(C([2H])([2H])[2H])(C4=CC(N5CCC(N6CCOCC6)CC5)=C(CC)C=C41)C([2H])([2H])[2H]
Molecular Weight
488.65
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Gadgeel S, et al. Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study. Ann Oncol. 2018 Nov 1;29(11):2214-2222.|[3]Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011, 19(5), 679-690.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1616374-19-6
Available Sizes
Curated Selection
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