BACE2-IN-1

BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].

Product Specifications

CAS Number

[1676107-08-6]

UNSPSC

12352005

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bace2-in-1.html

Purity

99.4

Solubility

DMSO : 62 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC(C)=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNCC3=CC=CC(C(F)(F)F)=C3)=O)=C1)N(C)[C@@H](C4=CC=CC=C4)C

Molecular Formula

C36H38F3N3O3

Molecular Weight

617.70

References & Citations

[1]Ghosh AK, et al. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. 2019 Mar 5. 14 (5) :545-560.